I run Wyred gear (DAC, Pre, and Amp) and was using MIT Shotgun S2 and S3 ICs and thought all was good. However, a few forum members mentioned that MIT ICs may not synergize well with the Wyred gear due to the impedence adjustments done by both the MIT cables and the Wyred gear. To test this theory I had Rob at AudioArt cables build me a couple pairs of hot rodded IC3s to replace the MITs. The AudioArt cables delivered substantially more crispness, sparkle, and resolution than I was getting with the MITs. The MITs sounded somewhat muddy in comparison. So synergy does matter and with Wyred gear AudioArt cables work very well.