Right now, I run all my speakers at small setting except my fronts to large and bass out to both sub and mains setting.
One of the reasons when I listen to 2-ch music I use my fronts only, not my sub. I love the "DIRECT STEREO" mode on my Yamaha RX-V1400. The sound is simply astounding warm and creamy and the bass is superb no need for sub at all even though I have Velodyne CHT-15 and I don't use it for music anymore. because my NAD C272 amp is rated at 150w RMS x 2, has lot of slam and punch for RT800i's. Love it!
Now, how about setting all my speakers to large setting. I use Adcom GFA 7605 125w RMS x 5 which has lot of power as well. I think by doing this it will show the difference in movies too.
I think if you run receiver, use small setting for all speakers but if you got separate amp(s) use large setting for all speakers, make sense! and why not?
What do you think?:)